University of Sussex
Browse
jphp_12569_proofs.pdf (2.14 MB)

Development and optimization of ketoconazole oral strips by means of continuous hot-melt extrusion processing

Download (2.14 MB)
journal contribution
posted on 2023-06-09, 01:12 authored by Mohammed Maniruzzaman, Smirna Farias, Ian J Slipper, Joshua S Boateng, Babur Z Chowdhry, Arun Nair, Dennis Douroumis
Objectives The aim of this study was to develop mucoadhesive oral strips using hot-melt extrusion as a continuous manufacturing process. Methods Powder blends of ketoconazole, a water-insoluble drug – either hydroxypropyl methylcellulose (HPMC) or soluplus (SOL), sorbitol (SRB) and magnesium aluminometasilicate (MAS) were extruded to manufacture thin strips with 0.5-mm thickness. The presence of the inorganic metasilicate facilitated smooth processing of the extruded strips as it worked as an absorbent directly impacting on the extensive mixing of the drug/excipients inside the extruder barrel. Key findings The use of MAS also favoured the rapid hydration, swelling and eventual disintegration of the strips. Differential scanning calorimetry and transmission X-ray diffraction analysis revealed the existence of the amorphous drug within the extruded strips. Scanning electron microscopy and energy dispersive X-ray undertaken on the formulations showed a homogeneous drug distribution within the extruded strips. Conclusion The strips produced via continuous hot-melt extrusion processing showed significantly faster release of ketoconazole compared to the bulk drug substance.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Journal of Pharmacy and Pharmacology

ISSN

0022-3573

Publisher

Royal Pharmaceutical Society of Great Britain / Wiley

Issue

7

Volume

68

Page range

890-900

Department affiliated with

  • Chemistry Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2016-05-12

First Open Access (FOA) Date

2017-05-12

First Compliant Deposit (FCD) Date

2016-05-12

Usage metrics

    University of Sussex (Publications)

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC