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Effects of Aß exposure on longterm associative memory and its neuronal mechanisms in a defined neuronal network

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posted on 2023-06-09, 01:11 authored by Lenzie Ford, Michael CrossleyMichael Crossley, Thomas Williams, Julian R Thorpe, Louise SerpellLouise Serpell, George KemenesGeorge Kemenes
Amyloid beta (Aß ) induced neuronal death has been linked to memory loss, perhaps the most devastating symptom of Alzheimer’s disease (AD). Although Aß -induced impairment of synaptic or intrinsic plasticity is known to occur before any cell death, the links between these neurophysiological changes and the loss of specific types of behavioral memory are not fully understood. Here we used a behaviorally and physiologically tractable animal model to investigate Aß -induced memory loss and electrophysiological changes in the absence of neuronal death in a defined network underlying associative memory. We found similar behavioral but different neurophysiological effects for Aß 25-35 and Aß 1-42 in the feeding circuitry of the snail Lymnaea stagnalis. Importantly, we also established that both the behavioral and neuronal effects were dependent upon the animals having been classically conditioned prior to treatment, since Aß application before training caused neither memory impairment nor underlying neuronal changes over a comparable period of time following treatment.

Funding

Amyloid structure and function; MRC; MR/K022105/1

Learning and memory mechanisms; BBSRC; BB/H009906/1

History

Publication status

  • Published

File Version

  • Published version

Journal

Scientific Reports

ISSN

2045-2322

Publisher

Nature Publishing Group

Volume

5

Page range

10614

Department affiliated with

  • Neuroscience Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2016-05-10

First Open Access (FOA) Date

2016-05-10

First Compliant Deposit (FCD) Date

2016-05-10

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