Stevenson, Jennifer, Parekh, Nikesh, Ali, Khalid, Timeyin, Jean, Bremner, Stephen, Van Der Cammen, Tischa, Allen, Jane, Schiff, Rebekah, Harchowal, Jatinder, Davies, Graham and Rajkumar, Chakravarthi (2016) Protocol for a Prospective (P) study to develop a model to stratify the risk (RI) of medication (M) related harm in hospitalized elderly (E) patients in the UK (the PRIME study). BMC Geriatrics, 16 (1). a22. ISSN 1471-2318

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Abstract

Abstract
BACKGROUND:

Medication related harm (MRH) is a common cause of morbidity and hospital admission in the elderly, and has significant cost implications for both primary and secondary healthcare resources. The development of risk prediction models has become an increasingly common phenomenon in medicine and can be useful to guide objective clinical decision making, resource allocation and intervention. There are no risk prediction models that are widely used in clinical practice to identify elderly patients at high risk of MRH following hospital discharge. The aim of this study is to develop a risk prediction model (RPM) to identify elderly patients at high risk of MRH upon discharge from hospital, and to compare this with routine clinical judgment.
METHODS/DESIGN:

This is a multi-centre, prospective observational study following a cohort of patients for 8 weeks after hospital discharge. Data collection including patient characteristics, medication use, social factors and frailty will take place prior to patient discharge and then the patient will be followed up in the community over the next 8 weeks to determine if they have experienced MRH. Research pharmacists will determine whether patients have experienced MRH by prospectively reviewing records for unplanned emergency department attendance, hospital readmission and GP consultation related to MRH. Research pharmacists will also telephone patients directly to determine self-reported MRH, which patients may not have sought further medical attention for. The data collected will inform the development of a RPM which will be externally validated in a follow-up study.
DISCUSSION:

There are no RPMs that are used in clinical practice to help stratify elderly patients at high risk of MRH in the community following hospital discharge, despite this being a significant public health problem. This study plans to develop a clinically useful RPM that is better than routine clinical judgment. As this is a multi-centre study involving clinical settings that serve elderly people of heterogeneous sociodemographic background, it is anticipated that this RPM will be generalizable.

Item Type:	Article
Keywords:	Elderly, Medication-related harm, Risk prediction, Prognostic research, Public health
Schools and Departments:	Brighton and Sussex Medical School > Brighton and Sussex Medical School Brighton and Sussex Medical School > Clinical and Experimental Medicine Brighton and Sussex Medical School > Primary Care and Public Health
Subjects:	R Medicine > R Medicine (General)
Related URLs:	Publisher
Depositing User:	Marie Shelton
Date Deposited:	22 Apr 2016 15:18
Last Modified:	19 Aug 2019 15:00
URI:	http://sro.sussex.ac.uk/id/eprint/60592

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