Longitudinal changes in functional brain connectivity predicts conversion to Alzheimer's disease

Serra, Laura, Cercignani, Mara, Mastropasqua, Chiara, Torso, Mario, Spanò, Barbara, Makovac, Elena, Viola, Vanda, Giulietti, Giovanni, Marra, Camillo, Caltagirone, Carlo and Bozzali, Marco (2016) Longitudinal changes in functional brain connectivity predicts conversion to Alzheimer's disease. Journal of Alzheimer's Disease, 51 (2). pp. 377-389. ISSN 1387-2877

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This longitudinal study investigates the modifications in structure and function occurring to typical Alzheimer's disease (AD) brains over a 2-year follow-up, from pre-dementia stages of disease, with the aim of identifying biomarkers of prognostic value. Thirty-one patients with amnestic mild cognitive impairment were recruited and followed-up with clinical, neuropsychological, and MRI assessments. Patients were retrospectively classified as AD Converters or Non-Converters, and the data compared between groups. Cross-sectional MRI data at baseline, assessing volume and functional connectivity abnormalities, confirmed previous findings, showing a more severe pattern of regional grey matter atrophy and default-mode network disconnection in Converters than in Non-Converters. Longitudinally, Converters showed more grey matter atrophy in the frontotemporal areas, accompanied by increased connectivity in the precuneus. Discriminant analysis revealed that functional connectivity of the precuneus within the default mode network at baseline is the parameter able to correctly classify patients in Converters and Non-Converters with high sensitivity, specificity, and accuracy.

Item Type: Article
Keywords: Alzheimer’s disease, Functional disconnection, Grey matter atrophy, Longitudinal study, Mild cognitive impairment
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
Subjects: R Medicine
R Medicine > R Medicine (General) > R895 Medical physics. Medical radiology. Nuclear medicine
R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0346 Neurology. Diseases of the nervous system Including speech disorders
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Depositing User: Patricia Butler
Date Deposited: 14 Jul 2016 14:55
Last Modified: 12 Nov 2019 12:08
URI: http://sro.sussex.ac.uk/id/eprint/60364
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