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Mutational patterns in oncogenes and tumour suppressors
journal contribution
posted on 2023-06-09, 00:47 authored by Hanadi M Baeissa, Graeme Benstead-Hume, Christopher J Richardson, Frances PearlFrances PearlAll cancers depend upon mutations in critical genes, which confer a selective advantage to the tumour cell. Knowledge of these mutations is crucial to understanding the biology of cancer initiation and progression, and to the development of targeted therapeutic strategies. The key to understanding the contribution of a disease-associated mutation to the development and progression of cancer, comes from an understanding of the consequences of that mutation on the function of the affected protein, and the impact on the pathways in which that protein is involved. In this paper we examine the mutation patterns observed in oncogenes and tumour suppressors, and discuss different approaches that have been developed to identify driver mutations within cancers that contribute to the disease progress. We also discuss the MOKCa database where we have developed an automatic pipeline that structurally and functionally annotates all proteins from the human proteome that are mutated in cancer.
History
Publication status
- Published
File Version
- Accepted version
Journal
Biochemical Society TransactionsISSN
0300-5127Publisher
Portland PressExternal DOI
Issue
3Volume
44Page range
952-931Department affiliated with
- Biochemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2016-04-05First Open Access (FOA) Date
2017-06-09First Compliant Deposit (FCD) Date
2016-04-05Usage metrics
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