Microwave-assisted Bohlmann–Rahtz synthesis of highly-substituted 2-aminonicotinates

Bagley, Mark C, Alnomsy, Ayed and Temple, Scott J (2016) Microwave-assisted Bohlmann–Rahtz synthesis of highly-substituted 2-aminonicotinates. SYNLETT, 27 (11). pp. 1728-1732. ISSN 0936-5214

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Microwave irradiation of 2-carbethoxyacetamidine and an ethynyl ketone under acidic or basic conditions in ethanol at 150 °C for 1.5 h facilitated Bohlmann-Rahtz pyridine synthesis to give highly-substituted ethyl 2 aminonicotinates with total regiocontrol and in reasonable to excellent yield, following purification by immobiliza tion upon an acidic resin.

Item Type: Article
Schools and Departments: School of Life Sciences > Chemistry
Depositing User: Mark Bagley
Date Deposited: 30 Mar 2016 07:06
Last Modified: 02 Jul 2019 19:18
URI: http://sro.sussex.ac.uk/id/eprint/60138

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Project NameSussex Project NumberFunderFunder Ref
Alignment of Synthesis, Medicinal Chemistry and Structural Genomics to Accelerate (Strathclyde lead)G0926EPSRC-ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCILRKES 115428
PhD Studentship21216348Saudi Cultural Bureaui532
Medicinal chemistry and drug discovery centreBS450-93R M Phillips TrustUnset