Feldwisch-Drentrup, Hinnerk, Barrett, Adam B, Smith, Michael T and van Rossum, Mark C W (2012) Fluctuations in the open time of synaptic channels: an application to noise analysis based on charge. Journal of Neuroscience Methods, 210 (1). pp. 15-21. ISSN 0165-0270

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Abstract

Synaptic channels are stochastic devices. Even recording from large ensembles of channels, the fluctuations, described by Markov transition matrices, can be used to extract single channel properties. Here we study fluctuations in the open time of channels, which is proportional to the charge flowing through the channel. We use the results to implement a novel type of noise analysis that uses the charge rather than the current to extract fundamental channel parameters. We show in simulations that this charge based noise analysis is more robust if the synapse is located on the dendrites and thus subject to cable filtering. However, we also demonstrate that when multiple synapses are distributed on the dendrites, noise analysis breaks down. We finally discuss applications of our results to other biological processes.

Item Type:	Article
Schools and Departments:	School of Engineering and Informatics > Informatics
Depositing User:	Adam Barrett
Date Deposited:	23 Mar 2016 14:31
Last Modified:	02 Jul 2019 22:50
URI:	http://sro.sussex.ac.uk/id/eprint/60137

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