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Fluctuations in the open time of synaptic channels: an application to noise analysis based on charge

journal contribution
posted on 2023-06-09, 00:39 authored by Hinnerk Feldwisch-Drentrup, Adam BarrettAdam Barrett, Michael T Smith, Mark C W van Rossum
Synaptic channels are stochastic devices. Even recording from large ensembles of channels, the fluctuations, described by Markov transition matrices, can be used to extract single channel properties. Here we study fluctuations in the open time of channels, which is proportional to the charge flowing through the channel. We use the results to implement a novel type of noise analysis that uses the charge rather than the current to extract fundamental channel parameters. We show in simulations that this charge based noise analysis is more robust if the synapse is located on the dendrites and thus subject to cable filtering. However, we also demonstrate that when multiple synapses are distributed on the dendrites, noise analysis breaks down. We finally discuss applications of our results to other biological processes.

Funding

Towards a next-generation computational neuroscience; G0305; EPSRC-ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCIL; EP/G007543/1

History

Publication status

  • Published

File Version

  • Published version

Journal

Journal of Neuroscience Methods

ISSN

0165-0270

Publisher

Elsevier

Issue

1

Volume

210

Page range

15-21

Department affiliated with

  • Informatics Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2016-03-23

First Compliant Deposit (FCD) Date

2016-03-23

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