020315_IEEE_Conf_SAS2016_Zebrafinal.pdf (425.25 kB)
Functional characterization of developing heart in embryos using Electric Potential Sensors
conference contribution
posted on 2023-06-09, 00:21 authored by Elizabeth Rendon-MoralesElizabeth Rendon-Morales, Robert Prance, Helen Prance, Rodrigo Aviles-EspinosaThe characterization of the electrocardiographic activity of the living zebrafish heart during early developmental stages is a challenging task. Most of the available techniques are limited to heartbeat rate quantification being this inaccurate. Other invasive methodologies require the insertion of electrodes noise isolated environments and advanced amplification stages making these techniques very expensive. In this paper, we present a novel and non-invasive sensor development to characterize the functional activity of the developing heart of in vivo zebrafish embryos. The design is based on the Electric Potential Sensing technology patented at Sussex which has been developed to achieve reproducibility and continuous detection. We present preliminary functional characterization data of the developing zebrafish heart starting at 3 days-post-fertilization. Results show that using the proposed system for mapping the electrocardiographic activity of the zebrafish heart at early developmental stages is successfully accomplished. This is the first time that such a sensitive sensor has been developed for measuring the electrical changes occurring on micron sized (< 100 µm) living samples such as the zebrafish heart.
History
Publication status
- Published
File Version
- Accepted version
Journal
SAS Sensors Applications Symposium April 20-22, 2016, Catania, Italy : proceedingsPublisher
Institute of Electrical and Electronics EngineersExternal DOI
Event name
IEEE Sensors Applications Symposium 2016Event location
Catania, ItalyEvent type
conferenceEvent date
April 20-23, 2016ISBN
9781479972500Department affiliated with
- Engineering and Design Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2016-03-02First Open Access (FOA) Date
2017-04-01First Compliant Deposit (FCD) Date
2016-03-02Usage metrics
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