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Functional characterization of developing heart in embryos using Electric Potential Sensors

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conference contribution
posted on 2023-06-09, 00:21 authored by Elizabeth Rendon-MoralesElizabeth Rendon-Morales, Robert Prance, Helen Prance, Rodrigo Aviles-Espinosa
The characterization of the electrocardiographic activity of the living zebrafish heart during early developmental stages is a challenging task. Most of the available techniques are limited to heartbeat rate quantification being this inaccurate. Other invasive methodologies require the insertion of electrodes noise isolated environments and advanced amplification stages making these techniques very expensive. In this paper, we present a novel and non-invasive sensor development to characterize the functional activity of the developing heart of in vivo zebrafish embryos. The design is based on the Electric Potential Sensing technology patented at Sussex which has been developed to achieve reproducibility and continuous detection. We present preliminary functional characterization data of the developing zebrafish heart starting at 3 days-post-fertilization. Results show that using the proposed system for mapping the electrocardiographic activity of the zebrafish heart at early developmental stages is successfully accomplished. This is the first time that such a sensitive sensor has been developed for measuring the electrical changes occurring on micron sized (< 100 µm) living samples such as the zebrafish heart.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

SAS Sensors Applications Symposium April 20-22, 2016, Catania, Italy : proceedings

Publisher

Institute of Electrical and Electronics Engineers

Event name

IEEE Sensors Applications Symposium 2016

Event location

Catania, Italy

Event type

conference

Event date

April 20-23, 2016

ISBN

9781479972500

Department affiliated with

  • Engineering and Design Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2016-03-02

First Open Access (FOA) Date

2017-04-01

First Compliant Deposit (FCD) Date

2016-03-02

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