Europium.pdf (1.34 MB)
Europium as an inhibitor of Amyloid-ß(1-42) induced membrane permeation
journal contribution
posted on 2023-06-09, 00:13 authored by Thomas L Williams, Brigita Urbanc, Karen E Marshall, Devkee M Vadukul, A Toby A Jenkins, Louise SerpellLouise SerpellSoluble Amyloid-beta (Aß) oligomers are a source of cytotoxicity in Alzheimer's disease (AD). The toxicity of Aß oligomers may arise from their ability to interact with and disrupt cellular membranes mediated by GM1 ganglioside receptors within these membranes. Therefore, inhibition of Aß–membrane interactions could provide a means of preventing the toxicity associated with Aß. Here, using Surface Plasmon field-enhanced Fluorescence Spectroscopy, we determine that the lanthanide, Europium III chloride (Eu3+), strongly binds to GM1 ganglioside-containing membranes and prevents the interaction with Aß42 leading to a loss of the peptides ability to cause membrane permeation. Here we discuss the molecular mechanism by which Eu3+ inhibits Aß42-membrane interactions and this may lead to protection of membrane integrity against Aß42 induced toxicity.
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Publication status
- Published
File Version
- Published version
Journal
FEBS LettersISSN
0014-5793Publisher
ElsevierExternal DOI
Issue
21Volume
589Page range
3228-3236Department affiliated with
- Biochemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2016-02-05First Open Access (FOA) Date
2016-02-05First Compliant Deposit (FCD) Date
2016-02-04Usage metrics
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