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Europium as an inhibitor of Amyloid-ß(1-42) induced membrane permeation

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posted on 2023-06-09, 00:13 authored by Thomas L Williams, Brigita Urbanc, Karen E Marshall, Devkee M Vadukul, A Toby A Jenkins, Louise SerpellLouise Serpell
Soluble Amyloid-beta (Aß) oligomers are a source of cytotoxicity in Alzheimer's disease (AD). The toxicity of Aß oligomers may arise from their ability to interact with and disrupt cellular membranes mediated by GM1 ganglioside receptors within these membranes. Therefore, inhibition of Aß–membrane interactions could provide a means of preventing the toxicity associated with Aß. Here, using Surface Plasmon field-enhanced Fluorescence Spectroscopy, we determine that the lanthanide, Europium III chloride (Eu3+), strongly binds to GM1 ganglioside-containing membranes and prevents the interaction with Aß42 leading to a loss of the peptides ability to cause membrane permeation. Here we discuss the molecular mechanism by which Eu3+ inhibits Aß42-membrane interactions and this may lead to protection of membrane integrity against Aß42 induced toxicity.

History

Publication status

  • Published

File Version

  • Published version

Journal

FEBS Letters

ISSN

0014-5793

Publisher

Elsevier

Issue

21

Volume

589

Page range

3228-3236

Department affiliated with

  • Biochemistry Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2016-02-05

First Open Access (FOA) Date

2016-02-05

First Compliant Deposit (FCD) Date

2016-02-04

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