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Development and characterisation of sodium alginate and HPMC films for mucosal drug delivery
journal contribution
posted on 2023-06-09, 00:11 authored by Dinesh Rai, Mohammed Maniruzzaman, Joshua S. BoatengThe aim of this work was to develop and evaluate sodium alginate (SA) and hydroxypropyl methylcellulose (HPMC) films as novel drug delivery systems for moist surfaces such as wounds, buccal and vaginal cavities. Films containing SA or HPMC and PEG 200 or glycerol were prepared by a solvent casting technique. Process optimisation was performed to establish the best experimental parameters for preparing the films. Physical appearance, ease of removal, tensile properties (tensile strength, % strain at break) and plasticiser leaching were investigated. These criteria formed the basis for further development formulations comprising optimum ratios of SA/HPMC and PEG 200/glycerol. The optimum polymer-plasticiser combinations were then selected for further characterisation of tensile, hydration, adhesive properties by texture analysis and surface morphology by scanning electron microscopy. The results showed the potential of developing both fast and controlled release mucosal formulations by a combination of the two polymers.
History
Publication status
- Published
Journal
International Journal of BiotechnologyISSN
0963-6048Publisher
InderscienceExternal DOI
Issue
3/4Volume
11Page range
169-181Department affiliated with
- Chemistry Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2016-01-29Usage metrics
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