University of Sussex
Browse

File(s) not publicly available

Sustained release solid lipid matrices processed by hot-melt extrusion (HME)

journal contribution
posted on 2023-06-09, 00:10 authored by K Vithani, M Maniruzzaman, I J Slipper, S Mostafa, C Miolane, Y Cuppok, D Marchaud, D Douroumis
The aim of this work was to develop sustained release solid lipid matrices of diclofenac sodium (Df-Na) processed by hot melt extrusion (HME) and subsequent compression into tablets. Different extrusion processing approaches such as “cold”, “hot” and pre-mixed formulations were used to develop the Compritol® 888 ATO lipid matrices by altering the extrusion temperatures, drug loading and formulation composition. The extrudates were characterized via a range of techniques such as differential scanning calorimetry (DSC), hot stage microscopy (HSM) and X-ray powder diffraction (XRPD) to identify the drug state within the lipid matrix. Df-Na was found to be either in crystalline or amorphous state depending on the processing conditions. Energy dispersive X-ray (EDX) microanalysis demonstrated excellent drug distribution of Df-Na on the surface of the compressed tablets. The lipid matrices developed by HME provided sustained release of pre-mixed formulations for 12 h mainly controlled by diffusion.

History

Publication status

  • Published

Journal

Colloids and Surfaces B: Biointerfaces

ISSN

0927-7765

Publisher

Elsevier

Volume

110

Page range

403-410

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2016-01-29

Usage metrics

    University of Sussex (Publications)

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC