Kaialy, Waseem and Nokhodchi, Ali (2016) The use of freeze-dried mannitol to enhance the in vitro aerosolization behaviour of budesonide from the Aerolizer®. Powder Technology, 288. pp. 291-302. ISSN 0032-5910
Full text not available from this repository.Abstract
The efficiency of drug delivery from drug-carrier dry powder inhaler (DPI) systems is typically low. The purpose of this study was to examine the aerosolization performance of a hydrophobic drug, budesonide (BUD), from DPI formulations containing a promising carrier, freeze-dried mannitol (FDM), and to compare the results to those obtained previously with a hydrophilic drug, salbutamol sulphate (SS).
The results showed that, in comparison to the formulation containing commercial BUD and commercial lactose, a total of 3.8-fold increase in the fine particle fraction (FPF) was obtained from the formulation containing FDM (FPF: 7.5% versus 29%) whereas a total of 4.6-fold increase in the FPF was obtained from the formulation containing FDM and leucine additive (FPF: 35%). Regression analysis showed DPI formulations containing carrier particles with a more elongated/less spherical shape, a higher content of fine particulates (< 5 μm) and a higher porosity to produce higher FPFs of BUD.
FDM promoted the aerosolization of budesonide intended for pulmonary delivery. The addition of leucine (by 4.8%, w/w) has further improved the flow and the aerosolization properties of FDM. FDM produced higher aerodynamic diameters and smaller FPFs of BUD as compared to SS, attributable to BUD having a higher electrostatic charge density and a higher agglomeration tendency than SS.
Item Type: | Article |
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Schools and Departments: | School of Life Sciences > Chemistry |
Depositing User: | Ali Nokhodchi |
Date Deposited: | 18 Jan 2016 13:02 |
Last Modified: | 18 Jan 2016 13:02 |
URI: | http://sro.sussex.ac.uk/id/eprint/59277 |