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DNA repair, genome stability and cancer: a historical perspective

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posted on 2023-06-09, 00:03 authored by Penny Jeggo, Laurence PearlLaurence Pearl, Antony CarrAntony Carr
The multistep process of cancer progresses over many years. The prevention of mutations by DNA repair pathways led to an early appreciation of a role for repair in cancer avoidance. However, the broader role of the DNA damage response (DDR) emerged more slowly. In this Timeline article, we reflect on how our understanding of the steps leading to cancer developed, focusing on the role of the DDR. We also consider how our current knowledge can be exploited for cancer therapy.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Nature Reviews Cancer

ISSN

1474-175X

Publisher

Nature Publishing Group

Issue

1

Volume

16

Page range

35-42

Department affiliated with

  • Sussex Centre for Genome Damage Stability Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2016-01-18

First Open Access (FOA) Date

2016-08-01

First Compliant Deposit (FCD) Date

2016-01-18

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