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Rates of lateral gene transfer in prokaryotes: high but why?
journal contribution
posted on 2023-06-09, 00:00 authored by Michiel Vos, Matthijn C Hesselman, Tim A te Beek, Mark W J van Passel, Adam Eyre-WalkerAdam Eyre-WalkerLateral gene transfer is of fundamental importance to the evolution of prokaryote genomes and has important practical consequences, as evidenced by the rapid dissemination of antibiotic resistance and virulence determinants. Relatively little effort has so far been devoted to explicitly quantifying the rate at which accessory genes are taken up and lost, but it is possible that the combined rate of lateral gene transfer and gene loss is higher than that of point mutation. What evolutionary forces underlie the rate of lateral gene transfer are not well understood. We here use theory developed to explain the evolution of mutation rates to address this question and explore its consequences for the study of prokaryote evolution.
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Publication status
- Published
Journal
Trends in MicrobiologyISSN
0966-842XPublisher
ElsevierExternal DOI
Issue
10Volume
23Page range
598-605Department affiliated with
- Evolution, Behaviour and Environment Publications
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- No
Peer reviewed?
- Yes
Legacy Posted Date
2016-01-15Usage metrics
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