Gilks, William P, Abbott, Jessica K and Morrow, Edward H (2014) Sex differences in disease genetics: evidence, evolution, and detection. Trends in Genetics, 30 (10). pp. 453-463. ISSN 0168-9525

Full text not available from this repository.

Abstract

Understanding the genetic architecture of disease is an enormous challenge, and should be guided by evolutionary principles. Recent studies in evolutionary genetics show that sexual selection can have a profound influence on the genetic architecture of complex traits. Here, we summarise data from heritability studies and genomewide association studies (GWASs) showing that common genetic variation influences many diseases and medically relevanttraits in a sex-dependent manner. In addition, we discuss how the discovery of sex-dependent effects in population samples is improved by joint interaction analysis (rather than separate-sex), as well as by recently developed software. Finally, we argue that although genetic variation that has sex-dependent effects on disease risk could be maintained by mutation–selection balance and genetic drift, recent evidence indicates that intralocus sexual conflict could be a powerful influence on complex trait architecture, and maintain sex-dependent disease risk alleles in a population because they are beneficial to the opposite sex.

Item Type:	Article
Schools and Departments:	School of Life Sciences > Evolution, Behaviour and Environment
Depositing User:	Ted Morrow
Date Deposited:	15 Jan 2016 13:06
Last Modified:	15 Jan 2016 13:06
URI:	http://sro.sussex.ac.uk/id/eprint/59180

📧 Request an update