Picao-Osorio, Joao, Johnston, Jamie, Landgraf, Matthias, Berni, Jimena and Alonso, Claudio R (2015) MicroRNA-encoded behavior in Drosophila. Science, 350 (6262). pp. 815-820. ISSN 0036-8075
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Abstract
The relationship between microRNA (miRNA) regulation and the specification of behavior is only beginning to be explored. We found that mutation of a single miRNA locus (miR-iab4/iab8) in Drosophila larvae affects the animal’s capacity to correct its orientation if turned upside down (self-righting). One of the miRNA targets involved in this behavior is the Hox gene Ultrabithorax, whose derepression in two metameric neurons leads to self-righting defects. In vivo neural activity analysis reveals that these neurons, the self-righting node (SRN), have different activity patterns in wild type and miRNA mutants, whereas thermogenetic manipulation of SRN activity results in changes in self-righting behavior. Our work thus reveals a miRNA-encoded behavior and suggests that other miRNAs might also be involved in behavioral control in Drosophila and other species.
Item Type: | Article |
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Schools and Departments: | School of Life Sciences > Neuroscience |
Related URLs: | |
Depositing User: | Claudio Alonso |
Date Deposited: | 15 Jan 2016 12:20 |
Last Modified: | 01 Mar 2021 15:11 |
URI: | http://sro.sussex.ac.uk/id/eprint/59175 |
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📧 Request an updateProject Name | Sussex Project Number | Funder | Funder Ref |
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The molecular regulation of Hox genes during animal development | G0952 | WELLCOME TRUST | 098410/Z/12/Z |