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A 8-hydroxyquinoline-cyclodextrin conjugate as an efficient chelating agent for cobalt(II) and nickel(II) in neutral aqueous solution

journal contribution
posted on 2023-06-08, 23:46 authored by Carmelo Sgarlata, Valentina Oliveri, John SpencerJohn Spencer
Chelating agents offer a versatile and effective means of removing toxic metal ions from the human body. Mounting evidence suggests that exposure to nickel and cobalt causes a number of adverse nasal/pulmonary health effects, skin hazards and allergies. In this context, the development of chelators that are able to bind nickel and cobalt with high stability constants is clearly crucial. Herein, the interaction of cobalt(II) and nickel(II) with a 8-hydroxyquinoline-cyclodextrin conjugate was investigated in aqueous solution at neutral pH. This family of chelator under study is potentially relevant in the treatment of diseases related to metal dyshomeostasis. Stability constants for the cobalt(II) and nickel(II) complexes were determined by competition experiments. The data indicate the formation of stable complexes, which were characterized by spectroscopic techniques. The collected information may provide new insights and suggest further strategies for the development of hydroxyquinoline derivatives for the control of cobalt and nickel toxicity.

Funding

Travel Grant - Collaboration: Bio-inoragnic Chemistry, Manganese Chelation & Cyclodextrins; G1401; Royal Society of Chemistry

NPC-C: Adding a Chemistry Element to Niemann-Pick C Research; G1484; NPRF

History

Publication status

  • Published

File Version

  • Accepted version

Journal

European Journal of Inorganic Chemistry

ISSN

1434-1948

Publisher

Wiley-VCH Verlag

Issue

36

Volume

2015

Page range

5886-5891

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2016-01-14

First Compliant Deposit (FCD) Date

2016-01-13

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