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Reactive Oxygen-Related Diseases - Therapeutic Targets and Emerging Clinical Indications.pdf (607.34 kB)

Reactive oxygen-related diseases: therapeutic targets and emerging clinical indications

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posted on 2023-06-08, 23:34 authored by Ana I Casas, V Thao-Vi Dao, Andreas Daiber, Ghassan J Maghzal, Fabio Di Lisa, Nina Kaludercic, Sonia Leach, Antonio Cuadrado, Vincent Jaquet, Tamara Seredenina, Karl H Krause, Manuela G López, Roland Stocker, Pietro Ghezzi, Harald H H W Schmidt
SIGNIFICANCE Enhanced levels of reactive oxygen species (ROS) have been associated with different disease states. Most attempts to validate and exploit these associations by chronic antioxidant therapies have provided disappointing results. Hence, the clinical relevance of ROS is still largely unclear. RECENT ADVANCES We are now beginning to understand the reasons for these failures, which reside in the many important physiological roles of ROS in cell signaling. To exploit ROS therapeutically, it would be essential to define and treat the disease-relevant ROS at the right moment and leave physiological ROS formation intact. This breakthrough seems now within reach. CRITICAL ISSUES Rather than antioxidants, a new generation of protein targets for classical pharmacological agents includes ROS-forming or toxifying enzymes or proteins that are oxidatively damaged and can be functionally repaired. FUTURE DIRECTIONS Linking these target proteins in future to specific disease states and providing in each case proof of principle will be essential for translating the oxidative stress concept into the clinic. Antioxid. Redox Signal. 23, 1171-1185.

History

Publication status

  • Published

File Version

  • Published version

Journal

Antioxidants and Redox Signaling

ISSN

1523-0864

Publisher

Mary Ann Liebert

Issue

14

Volume

23

Page range

1171-1185

Department affiliated with

  • Clinical and Experimental Medicine Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2015-11-27

First Open Access (FOA) Date

2015-11-27

First Compliant Deposit (FCD) Date

2015-11-27

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