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Cardiovascular and hepatic toxicity of cocaine: potential beneficial effects of modulators of oxidative stress

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posted on 2023-06-08, 23:14 authored by Manuela Graziani, Letizia Antonilli, Anna Rita Togna, Maria Caterina Grassi, Aldo Badiani, Luciano Saso
Oxidative stress (OS) is thought to play an important role in the pharmacological and toxic effects of various drugs of abuse. Herein we review the literature on the mechanisms responsible for the cardiovascular and hepatic toxicity of cocaine with special focus on OS-related mechanisms. We also review the preclinical and clinical literature concerning the putative therapeutic effects of OS modulators (such as N-acetylcysteine, superoxide dismutase mimetics, nitroxides and nitrones, NADPH oxidase inhibitors, xanthine oxidase inhibitors, and mitochondriotropic antioxidants) for the treatment of cocaine toxicity. We conclude that available OS modulators do not appear to have clinical efficacy.

History

Publication status

  • Published

File Version

  • Published version

Journal

Oxidative Medicine and Cellular Longevitiy

ISSN

1942-0900

Publisher

Hindawi Publishing Corporation

Volume

2016

Department affiliated with

  • Psychology Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2015-11-19

First Open Access (FOA) Date

2016-01-04

First Compliant Deposit (FCD) Date

2015-11-19

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