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Targeting tumor-stroma crosstalk: the example of the NT157 inhibitor

journal contribution
posted on 2023-06-08, 23:02 authored by T Rampias, R Favicchio, J Stebbing, Georgios GiamasGeorgios Giamas
Recent clinical research has provided evidence that cancer progression and therapy resistance is driven not only by tumor’s genetic profile but also by complex paracrine interactions within the tumor microenvironment (TME). The role of TME in modulating tumor drug sensitivity is increasingly recognized and targeting TME has been the focus of novel therapeutic approaches. Two recent reports show that a new anti-cancer drug, the inhibitor NT157 has the potential to inhibit IGF-1R and STAT3 signaling pathways in cancer cells and stoma cells of TME leading to a decrease in cancer cell survival.

History

Publication status

  • Published

Journal

Oncogene

ISSN

0950-9232

Publisher

Nature Publishing Group

Issue

20

Volume

35

Page range

2562-2564

Department affiliated with

  • Biochemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2015-11-04

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