File(s) under permanent embargo
Opiate versus psychostimulant addiction: the differences do matter
journal contribution
posted on 2023-06-08, 22:57 authored by Aldo Badiani, David Belin, David Epstein, Donna Calu, Yavin ShahamThe publication of the psychomotor stimulant theory of addiction in 1987 and the finding that addictive drugs increase dopamine concentrations in the rat mesolimbic system in 1988 have led to a predominance of psychobiological theories that consider addiction to opiates and addiction to psychostimulants as essentially identical phenomena. Indeed, current theories of addiction - hedonic allostasis, incentive sensitization, aberrant learning and frontostriatal dysfunction - all argue for a unitary account of drug addiction. This view is challenged by behavioural, cognitive and neurobiological findings in laboratory animals and humans. Here, we argue that opiate addiction and psychostimulant addiction are behaviourally and neurobiologically distinct and that the differences have important implications for addiction treatment, addiction theories and future research.
History
Publication status
- Published
File Version
- Published version
Journal
Nature Reviews NeuroscienceISSN
1471-003XPublisher
Nature ResearchExternal DOI
Issue
11Volume
12Page range
685-700Department affiliated with
- Psychology Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2015-10-28First Compliant Deposit (FCD) Date
2015-10-28Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC