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Cytokine and growth factor profiling in patients with the metabolic syndrome
journal contribution
posted on 2023-06-08, 22:55 authored by Seyed Reza Mirhafez, Alireza Pasdar, Amir Avan, Habibollah Esmaily, Atefeh Moezzi, Mohsen Mohebati, Zahra Meshkat, Hassan Mehrad-Majd, Saied Eslami, Hamid Reza Rahimi, Hamed Ghazavi, Gordon FernsGordon Ferns, Majid Ghayour-MobarhanThe metabolic syndrome (MetS) is associated with a pro-inflammatory milieu that may partially account for its association with an increased cardiovascular risk. We aimed to (1) evaluate the serum concentrations of twelve cytokines and growth factors (epidermal growth factor (EGF), interferon-γ (IFN-γ), IL-1α/-1β/-2/-4/-6/-8/-10, monocyte chemoattractant protein-1 (MCP-1), TNF-α and vascular endothelial growth factor (VEGF)) in 303 individuals with or without the MetS; and (2) explore their relationship with the presence of the MetS. Patients with the MetS had significantly higher serum concentrations of IFN-γ, EGF, IL-1α/-1β/-2/-4/-6/-8/-10, MCP-1 and TNF-α, whilst serum VEGF concentrations were markedly lower compared with the control group (e.g. 38-55 v. 82-18 pg/ml; P<0-05). Amongst these parameters, IFN-γ and IL-1α emerged as the most significant independent predictors of the MetS. In conclusion, our findings demonstrate that patients with the MetS had an altered blood cytokine and growth factor profile that may partially account for its adverse clinical outcomes. Further prospective studies in larger multi-centre settings are required to unravel the role and association of the emerging biomarkers with the MetS and their implication in therapeutic intervention. Copyright © The Authors 2015.
History
Publication status
- Published
Journal
British Journal of NutritionISSN
0007-1145Publisher
Cambridge University PressExternal DOI
Issue
12Volume
113Page range
1911-1919Department affiliated with
- Division of Medical Education Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2015-10-26Usage metrics
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