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The role of PARPs in DNA strand break repair
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posted on 2023-06-08, 22:34 authored by Stuart L Rulten, Francoise Dantzer, Keith CaldecottKeith CaldecottADP-ribosylation is a post-translational modification in which a target protein becomes modified with monomeric, short chains, or long branching chains of ADP-ribose (ADPR). The process can be carried out by a number of ADP-ribosyltransferases and polymerases (ADP-RTs and PARPs) and the consequences of ribosylation are as diverse and heterogeneous as the products that are formed. In mammalian cells, only three PARPs bind to DNA, and their activity is stimulated by DNA ends. A number of roles for these three PARPs have been characterised, including several functions in DNA repair. The known repertoire of ADPR-binding proteins is vastly expanding, meaning that ribosylation increases the rate and complexity of ways in which DNA is repaired by a number of different ways.
History
Publication status
- Published
ISSN
2196-9906Publisher
Humana PressExternal DOI
Volume
83Page range
47-78Pages
591.0Book title
PARP Inhibitors for Cancer TherapyPlace of publication
New YorkISBN
9783319141503Series
Cancer Drug Discovery and DevelopmentDepartment affiliated with
- Sussex Centre for Genome Damage Stability Publications
Full text available
- No
Peer reviewed?
- Yes
Editors
Ricky A Sharma, Nicola J CurtinLegacy Posted Date
2015-09-18Usage metrics
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