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Ontogeny and insulin-dependence of the satiation which follows carbohydrate absorption in the rat
journal contribution
posted on 2023-06-08, 22:18 authored by David A Booth, Simon P JarmanIn adult rats, the first meal on restoring access to food following the complete absorption of an intragastric carbohydrate load is smaller than the meal following a nonnutritive load. The weanling rat does not show this postabsorptively induced satiation. The effect does not appear until above a body weight of about 200 g. Subcutaneous injection of a moderate dose of insulin (0.2 units/kg) at the time of glucose intubation results in postabsorptive satiety appearing in the immature rat. The inhibitor of insulin secretion, D-mannoheptulose, injected shortly before glucose intubation, considerably reduces the satiety effect in the 300 g rat. It is suggested that an abundant secretion of insulin during absorption is necessary to establish the parenteral satiety signal operative under these conditions.
History
Publication status
- Published
Journal
Behavioral BiologyISSN
0091-6773Publisher
Academic PressExternal DOI
Issue
2Volume
15Page range
159-172Department affiliated with
- Psychology Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2015-09-01Usage metrics
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