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Ontogeny and insulin-dependence of the satiation which follows carbohydrate absorption in the rat

journal contribution
posted on 2023-06-08, 22:18 authored by David A Booth, Simon P Jarman
In adult rats, the first meal on restoring access to food following the complete absorption of an intragastric carbohydrate load is smaller than the meal following a nonnutritive load. The weanling rat does not show this postabsorptively induced satiation. The effect does not appear until above a body weight of about 200 g. Subcutaneous injection of a moderate dose of insulin (0.2 units/kg) at the time of glucose intubation results in postabsorptive satiety appearing in the immature rat. The inhibitor of insulin secretion, D-mannoheptulose, injected shortly before glucose intubation, considerably reduces the satiety effect in the 300 g rat. It is suggested that an abundant secretion of insulin during absorption is necessary to establish the parenteral satiety signal operative under these conditions.

History

Publication status

  • Published

Journal

Behavioral Biology

ISSN

0091-6773

Publisher

Academic Press

Issue

2

Volume

15

Page range

159-172

Department affiliated with

  • Psychology Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2015-09-01

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