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Tolerance in the depression of intake when amphetamine is added to the rat's food

journal contribution
posted on 2023-06-08, 22:17 authored by Jaak Panksepp, D A Booth
The depression of intake initially seen when a rat is placed on an amphetamine adulterated diet disappears over a week at the dose level of 0.2 mg amphetamine per gram of chow. The decreased effectiveness of amphetamine is attributable primarily to accruing deprivation rather than to either behavioral or pharmacological tolerance. Ventromedial hypothalamic lesions attenuate the tolerance, whereas lateral hypothalamic lesions decrease the basic anorexigenic effect of amphetamine.

History

Publication status

  • Published

Journal

Psychopharmacologia

ISSN

0033-3158

Publisher

Springer

Issue

1

Volume

29

Page range

45-54

Department affiliated with

  • Psychology Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2015-09-01

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