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Tolerance in the depression of intake when amphetamine is added to the rat's food
journal contribution
posted on 2023-06-08, 22:17 authored by Jaak Panksepp, D A BoothThe depression of intake initially seen when a rat is placed on an amphetamine adulterated diet disappears over a week at the dose level of 0.2 mg amphetamine per gram of chow. The decreased effectiveness of amphetamine is attributable primarily to accruing deprivation rather than to either behavioral or pharmacological tolerance. Ventromedial hypothalamic lesions attenuate the tolerance, whereas lateral hypothalamic lesions decrease the basic anorexigenic effect of amphetamine.
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Publication status
- Published
Journal
PsychopharmacologiaISSN
0033-3158Publisher
SpringerExternal DOI
Issue
1Volume
29Page range
45-54Department affiliated with
- Psychology Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2015-09-01Usage metrics
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