s13075-015-0645-y.pdf (644.84 kB)
Pattern recognition receptors as potential therapeutic targets in inflammatory rheumatic disease
journal contribution
posted on 2023-06-08, 22:15 authored by Lisa MullenLisa Mullen, Giselle Chamberlain, Sandra SacreSandra SacreThe pattern recognition receptors of the innate immune system are part of the first line of defence against pathogens. However, they also have the ability to respond to danger signals that are frequently elevated during tissue damage and at sites of inflammation. Inadvertent activation of pattern recognition receptors has been proposed to contribute to the pathogenesis of many conditions including inflammatory rheumatic diseases. Prolonged inflammation most often results in pain and damage to tissues. In particular, the Toll-like receptors and nucleotide-binding oligomerisation domain-like receptors that form inflammasomes have been postulated as key contributors to the inflammation observed in rheumatoid arthritis, osteoarthritis, gout and systemic lupus erythematosus. As such, there is increasing interest in targeting these receptors for therapeutic treatment in the clinic. Here the role of pattern recognition receptors in the pathogenesis of these diseases is discussed, with an update on the development of interventions to modulate the activity of these potential therapeutic targets.
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Publication status
- Published
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- Published version
Journal
Arthritis Research & TherapyISSN
1478-6362Publisher
BioMed CentralExternal DOI
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1Volume
17Page range
122Department affiliated with
- Clinical and Experimental Medicine Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2015-08-28First Open Access (FOA) Date
2015-08-28First Compliant Deposit (FCD) Date
2015-08-28Usage metrics
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