McGuigan, Christopher, Derudas, Marco, Bugert, Joachim J, Andrei, Graciela, Snoeck, Robert and Balzarini, Jan (2008) Successful kinase bypass with new acyclovir phosphoramidate prodrugs. Bioorganic and Medicinal Chemistry Letters, 18 (15). pp. 4364-4367. ISSN 0960-894X

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Abstract

Novel phosphoramidates of acyclovir have been prepared and evaluated in vitro against acyclovir-sensitive and -resistant herpes simplex virus (HSV) types 1 and 2 and varicella-zoster virus (VZV). Unlike the parent nucleoside these novel phosphate prodrugs retain antiviral potency versus the ACV-resistant virus strain, suggesting an efficient bypass of the viral thymidine kinase.

Item Type:	Article
Schools and Departments:	School of Life Sciences > Chemistry
Depositing User:	Marco Derudas
Date Deposited:	28 Jul 2015 12:16
Last Modified:	28 Jul 2015 12:16
URI:	http://sro.sussex.ac.uk/id/eprint/55790

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