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Successful kinase bypass with new acyclovir phosphoramidate prodrugs
journal contribution
posted on 2023-06-08, 21:54 authored by Christopher McGuigan, Marco Derudas, Joachim J Bugert, Graciela Andrei, Robert Snoeck, Jan BalzariniNovel phosphoramidates of acyclovir have been prepared and evaluated in vitro against acyclovir-sensitive and -resistant herpes simplex virus (HSV) types 1 and 2 and varicella-zoster virus (VZV). Unlike the parent nucleoside these novel phosphate prodrugs retain antiviral potency versus the ACV-resistant virus strain, suggesting an efficient bypass of the viral thymidine kinase.
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Publication status
- Published
Journal
Bioorganic and Medicinal Chemistry LettersISSN
0960-894XPublisher
ElsevierExternal DOI
Issue
15Volume
18Page range
4364-4367Department affiliated with
- Chemistry Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2015-07-28Usage metrics
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