McGuigan, Christopher, Bidet, Olivier, Derudas, Marco, Andrei, Graciela, Snoeck, Robert and Balzarini, Jan (2009) Alkenyl substituted bicyclic nucleoside analogues retain nanomolar potency against Varicella Zoster Virus. Bioorganic and Medicinal Chemistry, 17 (8). pp. 3025-3027. ISSN 0968-0896

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Abstract

Novel alkenyl substituted aryl bicyclic furano pyrimidines have been prepared and evaluated in vitro against Varicella Zoster Virus (VZV). The para-substituted analogues retain the nanomolar potency we have reported for p-alkyl analogues, while the ortho- and meta-alkenyl systems lose 3–4 orders of potency.

Item Type:	Article
Schools and Departments:	School of Life Sciences > Chemistry
Depositing User:	Marco Derudas
Date Deposited:	28 Jul 2015 11:23
Last Modified:	28 Jul 2015 11:23
URI:	http://sro.sussex.ac.uk/id/eprint/55786

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