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Whale, Richard, Fialho, Renata Sofia, Rolt, Michael, Eccles, Jessica, Pereira, Marco, Keller, Majella, File, Alexandra, Haq, Inam and Tibble, Jeremy (2015) Psychomotor retardation and vulnerability to interferon alpha induced major depressive disorder: prospective study of a chronic hepatitis C cohort. Journal of Psychosomatic Research, 79 (6). pp. 640-645. ISSN 0022-3999
Full text not available from this repository.Abstract
BACKGROUND:
Major depressive disorder (MDD) is a common consequence of interferon alpha (IFNα) treatment and important supporting evidence of a role of inflammation in the aetiology of depression.
OBJECTIVE:
This study aimed to expand the knowledge of baseline clinical vulnerability characteristics to IFNα induced MDD, particularly exploring sub-threshold depressive symptoms.
METHODS:
A prospective cohort of chronic HCV patients undergoing treatment with pegylated-IFNα and ribavirin was studied. MDD was assessed using the Structured Clinical Interview for DSM-IV (SCID-I). Depressive symptoms and severity were assessed at baseline and monthly with the Hamilton Depression Rating Scale (HAMD). Subjects with MDD or taking antidepressant treatment at baseline were excluded.
RESULTS:
278 patients were assessed for this cohort with a final study sample of 190. 94.2% had contracted HCV through intravenous drug use. During six months IFNα treatment, 53.2% of patients transitioned to DSM-IV threshold MDD. In the multivariate logistic analysis, independent factors significantly associated with development of MDD were younger age (OR 0.96, 95% CI 0.93-1.00, p=0.028), past history of MDD (OR 3.82, 95% CI 1.63-8.92, p=0.002), baseline HAMD items psychomotor retardation (OR 15.21, 95% CI 1.33-173.41, p=0.032) and somatic symptoms (general) (OR 2.96, 95% CI 1.44-6.08, p=0.003), and HCV genotype 2 (OR 2.27, 95% CI 1.07-4.78, p=0.032).
CONCLUSIONS:
During IFNα treatment, the rate of transition to MDD was high in this cohort. Psychomotor retardation and somatic symptoms may represent a greater inflamed state pre-treatment. This iatrogenic model of MDD may offer important insights into wider depression aetiology.
| Item Type: | Article |
|---|---|
| Keywords: | Depressive disorder; Inflammation; Hepatitis C; Interferon-alpha; Prospective studies |
| Schools and Departments: | Brighton and Sussex Medical School > Division of Medical Education Brighton and Sussex Medical School > Neuroscience |
| Subjects: | Q Science > QZ Psychology R Medicine R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0438 Psychiatry |
| Depositing User: | Elizabeth Morris |
| Date Deposited: | 23 Jul 2015 15:09 |
| Last Modified: | 25 Jul 2017 14:13 |
| URI: | http://sro.sussex.ac.uk/id/eprint/55709 |