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Design and synthesis of novel polycycles based on the 3H-pyrrolo/6,7-dihydropyrido[1,2-a]indole scaffold as templates for pharmaceutical development

journal contribution
posted on 2023-06-08, 21:49 authored by Marco Derudas, Nicolino Pala, Vanna Sanna, Roberto Dallocchio, Alessandro Dessì, Anna Maria Roggio, Mario Sechi
In the course of our work aimed at developing novel heterocycles of pharmaceutical interest, we designed and synthesized several polycyclic templates as potential substrates to be used in drug design. We obtained a set of condensed ring systems as versatile structural platforms to generate potential DNA-interactive agents and/or reversible inhibitors of enzymes such as topoisomerases, poly(ADP-ribose) polymerase-1 (PARP-1), telomerase, and, in particular, cyclin dependent kinases. Herein, we report the design, synthesis, structural investigation, and preliminary DNA-binding affinity of these heteroaromatic systems. J. Heterocyclic Chem., (2011).

History

Publication status

  • Published

Journal

Journal of Heterocyclic Chemistry

ISSN

0022-152X

Publisher

Wiley

Issue

5

Volume

48

Page range

1161-1168

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2015-07-22

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