Gomaa, Mohamed F Y, Pala, Nicolino, Derudas, Marco, Hasanen, Jehan Abd-Elrazik, El-Tamany, El-Sayed H, Casule, Paola, Mariani, Alberto and Sechi, Mario (2011) Investigation of furo[2,3-h]- and pyridazino[3,4-f]cinnolin-3-ol scaffolds as substrates for the development of novel HIV-1 integrase inhibitors. Arkivoc, 2011 (9). pp. 1-14. ISSN 1551-7012
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Abstract
With the aim to develop novel HIV-1 integrase inhibitors, we obtained a set of condensed ring systems based on the furo[2,3-h]cinnolin-3(2H)-one and pyridazino[3,4-f]cinnolin-3-ol scaffolds bearing a potential chelating pharmacophore, which can be involved in the inhibition mechanism of the enzyme. Herein, we report the design, synthesis, structural investigation and preliminary biological results of these heteroaromatic systems.
Item Type: | Article |
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Schools and Departments: | School of Life Sciences > Chemistry |
Depositing User: | Marco Derudas |
Date Deposited: | 23 Jul 2015 06:14 |
Last Modified: | 02 Jul 2019 20:07 |
URI: | http://sro.sussex.ac.uk/id/eprint/55679 |
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