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The regulatory roles of phosphatases in cancer
journal contribution
posted on 2023-06-08, 21:28 authored by J Stebbing, L C Lit, H Zhang, R S Darrington, O Melaiu, B Rudraraju, Georgios GiamasGeorgios GiamasThe relevance of potentially reversible post-translational modifications required for controlling cellular processes in cancer is one of the most thriving arenas of cellular and molecular biology. Any alteration in the balanced equilibrium between kinases and phosphatases may result in development and progression of various diseases, including different types of cancer, though phosphatases are relatively under-studied. Loss of phosphatases such as PTEN (phosphatase and tensin homologue deleted on chromosome 10), a known tumour suppressor, across tumour types lends credence to the development of phosphatidylinositol 3-kinase inhibitors alongside the use of phosphatase expression as a biomarker, though phase 3 trial data are lacking. In this review, we give an updated report on phosphatase dysregulation linked to organ-specific malignancies.
History
Publication status
- Published
Journal
OncogeneISSN
1476-5594Publisher
Nature Publishing GroupExternal DOI
Issue
8Volume
33Page range
939-953Department affiliated with
- Biochemistry Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2015-07-07Usage metrics
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