LATS2 is a modulator of estrogen receptor alpha

Lit, Lei Cheng, Scott, Susan, Zhang, Hua, Stebbing, Justin, Photiou, Andrew and Giamas, Georgios (2013) LATS2 is a modulator of estrogen receptor alpha. Anticancer Research, 33 (1). pp. 53-63. ISSN 0250-7005

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Estrogen Receptor α (ERα), a member of the nuclear receptor superfamily of transcription factors, plays a central role in breast cancer development. More than two-thirds of patients with breast cancer are ERα-positive; however, a proportion becomes resistant. Phosphorylation of ERα is one of the mechanisms associated with resistance to endocrine therapy. In a kinome screen, we have identified the large tumor suppressor homolog-2 (LATS2) as a potential kinase, acting on ERα.


The role of LATS2 on activation of ERα transcription and its functional consequences was examined by various molecular and cellular biology techniques.


LATS2 co-localises with ERα in the nucleus. LATS2-silencing increases expression of ERα-regulated genes and inhibits proliferation. At the protein level, inhibition of LATS2 reduces the expression of cyclin-D1 and Nuclear Receptor Co-Repressor (NCoR) while increasing the expression of p27.


Identifying novel kinases which modulate ERα activity is relevant to therapeutics. LATS2 modulates ERα-regulated gene transcription, through direct and/or indirect interactions with ERα.

Item Type: Article
Schools and Departments: School of Life Sciences > Biochemistry
Depositing User: Georgios Giamas
Date Deposited: 07 Jul 2015 08:08
Last Modified: 07 Jul 2015 08:08
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