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Kinases as targets in the treatment of solid tumors
journal contribution
posted on 2023-06-08, 21:27 authored by Georgios GiamasGeorgios Giamas, Yik L Man, Heidrun Hirner, Joachim Bischof, Klaus Kramer, Kalimullah Khan, Sharmeen S Lavina Ahmed, Justin Stebbing, Uwe KnippschildThe protein kinase family, one of the largest gene families in eukaryotes, plays an important role in regulating various cellular processes such as cell proliferation, cell death, cell cycle progression, differentiation and cell survival. Therefore, it is not surprising that the deregulation of many kinases is usually directly linked to cancer development. In all solid tumors, changes in protein kinase expression levels and activities, as well as alterations in the degree of posttranslational modifications can contribute to cancer development. Consequently, the identification of molecular targets and signaling pathways specific to cancer cells is becoming more and more important for cancer drug development and cancer therapies. Inhibition of various protein kinases has already been investigated in many pre-clinical and clinical trials targeting all stages of signal transduction, demonstrating promising results in cancer therapy. Conventional chemotherapeutics are often ineffective as well as harmful; hence a combination of both chemotherapeutics and protein kinase inhibitors may result in new and more successful therapeutic approaches. In this review we focus on protein kinases involved in different signaling pathways and their alterations in solid tumors.
History
Publication status
- Published
Journal
Cellular SignallingISSN
0898-6568Publisher
ElsevierExternal DOI
Issue
7Volume
22Page range
984-1002Department affiliated with
- Biochemistry Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2015-07-07Usage metrics
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