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Casein kinase 1 delta (CK1delta) interacts with the SNARE associated protein snapin
journal contribution
posted on 2023-06-08, 21:27 authored by Sonja Wolff, Martin Stöter, Georgios GiamasGeorgios Giamas, Matthias Piesche, Doris Henne-Bruns, George Banting, Uwe KnippschildIn this study we identified snapin as an interaction partner of the CK1 isoform delta (CK1delta) in the yeast two-hybrid system and localized the interacting domains of both proteins. The interaction of CK1delta with snapin was confirmed by co-immunoprecipitation. Snapin was phosphorylated by CK1delta in vitro. Both proteins localized in close proximity in the perinuclear region, wherein snapin was found to associate with membranes of the Golgi apparatus. The identification of snapin as a new substrate of CK1delta points towards a possible function for CK1delta in modulating snapin specific functions.
History
Publication status
- Published
Journal
FEBS LettersISSN
0014-5793Publisher
ElsevierExternal DOI
Issue
27Volume
580Page range
6477-6484Department affiliated with
- Biochemistry Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2015-07-07Usage metrics
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