Sanchez-Roige, Sandra, Lalanza, Jaume F, Alvarez-López, María Jesús, Cosín-Tomás, Marta, Griñan-Ferré, Christian, Pallàs, Merce, Kaliman, Perla and Escorihuela, Rosa M (2014) Long-term wheel running changes on sensorimotor activity and skeletal muscle in male and female mice of accelerated senescence. AGE, 36 (5). ISSN 0161-9152

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Abstract

The senescence-accelerated mouse prone 8 (SAMP8) is considered a useful non-transgenic model for studying aspects of aging. Using SAM resistant 1 (SAMR1) as controls, the long-term effects of wheel running on skeletal muscle adaptations and behavioral traits were evaluated in senescent (P8) and resistant (R1) male and female mice. Long-term wheel running (WR) led to increases in locomotor activity, benefits in sensorimotor function, and changes in body weight in a gender-dependent manner. WR increased body weight and baseline levels of locomotor activity in female mice and improved balance and strength in male mice, compared to sedentary-control mice. WR resulted in key metabolic adaptations in skeletal muscle, associated with an increased activity of the sirtuin 1–AMP-activated protein kinase (AMPK)–PGC-1 alpha axis and changes in vascular endothelial growth factor A (Vegfa), glucose transporter type 4 (Glut4), and Cluster of Differentiation 36 (Cd36) gene expression. Overall, our data indicate that activity, balance, and strength decrease with age and that long-term WR may significantly improve the motor function in a mouse model of senescence in a gender-dependent manner.

Item Type:	Article
Schools and Departments:	School of Psychology > Psychology
Depositing User:	Nikoleta Kiapidou
Date Deposited:	30 Jun 2015 12:58
Last Modified:	02 Jul 2019 22:34
URI:	http://sro.sussex.ac.uk/id/eprint/55068

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