Serra, Laura, Musicco, Massimo, Cercignani, Mara, Torso, Mario, Spanò, Barbara, Mastropasqua, Chiara, Giulietti, Giovanni, Marra, Camillo, Bruno, Giuseppe, Koch, Giacomo, Caltagirone, Carlo and Bozzali, Marco (2015) Cognitive reserve and the risk for Alzheimer's disease: a longitudinal study. Neurobiology of Aging, 36 (2). pp. 592-600. ISSN 0197-4580

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Abstract

This study investigates how cognitive reserve (CR) interacts with neurodegeneration (quantified by medial temporal atrophy, MTA) and macroscopic white matter lesions (WMLs) in delaying the conversion from amnestic mild cognitive impairment to Alzheimer's disease (AD). Forty-two amnestic mild cognitive impairment patients were consecutively recruited. They underwent magnetic resonance imaging and a comprehensive questionnaire to classify them as individuals with low or high CR. Patients were then clinically followed-up for 2 years. The patients' risk for conversion to AD because of CR was estimated by controlling for cognitive efficiency, MTA, and WMLs at baseline. Global cognition was the best predictor of conversion to AD in low CR patients. Conversely, in high CR patients only, WMLs (but not MTA) highly contributed in increasing the risk for conversion to AD. In conclusion, CR interacts with both patients' cognitive features and WMLs in modulating the impact of AD pathology. This seems relevant for clinical prognosis and therapeutic strategies.

Item Type:	Article
Keywords:	Cognitive reserve; a-MCI; AD; Relative risk; MTA; White matter lesions
Schools and Departments:	Brighton and Sussex Medical School > Neuroscience
Subjects:	R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0346 Neurology. Diseases of the nervous system Including speech disorders
Depositing User:	Patricia Butler
Date Deposited:	27 Nov 2015 08:03
Last Modified:	24 Jul 2017 17:30
URI:	http://sro.sussex.ac.uk/id/eprint/54569

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