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Balendra, Rubika, Jones, Ashley, Jivraj, Naheed, Knights, Catherine, Ellis, Catherine M, Burman, Rachel, Turner, Martin R, Leigh, Nigel, Shaw, Christopher E and Al-Chalabi, Ammar (2014) Estimating clinical stage of amyotrophic lateral sclerosis from the ALS functional rating scale. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 15 (3-4). pp. 279-284. ISSN 2167-8421
Full text not available from this repository.Abstract
ALS is a progressive neurodegenerative disease. The stage of disease reached can be described using a simple system based on the number of central nervous system regions involved. Historically, datasets have not attempted to record clinical stage, but being able to re-analyse the data by stage would have several advantages. We therefore explored the possibility of using an algorithm based on the revised ALS Functional Rating Scale (ALSFRS-R), which is commonly used in clinical practice, to estimate clinical stage. We devised an algorithm to convert ALSFRS-R score into clinical stage. ALSFRS-R domains were mapped to equivalent CNS regions. Stage 4 is reached when gastrostomy or non- invasive ventilation is needed, but as a proxy we used provision. We collected ALSFRS-R from clinic visits, and compared the estimation of clinical stage from the ALSFRS-R with the actual stage. Results showed that the agreement between staging by the two methods was excellent with an intraclass correlation coefficient of 0.92 (95% confidence interval 0.88-0.94). There was no systematic bias towards over-staging or under-staging using the algorithm. In conclusion, we have shown that clinical stage in ALS can be reliably estimated using the ALSFRS-R in historical data and in current data where stage has not been recorded.
| Item Type: | Article |
|---|---|
| Schools and Departments: | Brighton and Sussex Medical School > Neuroscience |
| Subjects: | R Medicine R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0346 Neurology. Diseases of the nervous system Including speech disorders |
| Depositing User: | Patricia Butler |
| Date Deposited: | 25 Aug 2015 12:36 |
| Last Modified: | 21 Oct 2019 14:02 |
| URI: | http://sro.sussex.ac.uk/id/eprint/54190 |