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Health utility decreases with increasing clinical stage in amyotrophic lateral sclerosis
journal contribution
posted on 2023-06-08, 20:56 authored by Ashley R Jones, Naheed Jivraj, Rubika Balendra, Caroline Murphy, Joanna Kelly, Marie Thornhill, Carolyn Young, Pamela J Shaw, Nigel LeighNigel Leigh, Martin R Turner, I Nick Steen, Paul McCrone, Ammar Al-ChalabiAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease typically causing death within three years. Understanding the impact of disease on patients using health utility at different stages of ALS would allow meaningful cost-benefit analysis of new potential therapies. A common health-related quality of life measurement, developed and validated for the UK, is the EQ-5D. Using clinical trial data from the LiCALS study, we calculated health utility using the EQ-5D for each King's ALS clinical stage from 214 patients. We analysed whether health utility, and other health-related measures, significantly changed between each of the clinical stages. Results showed that mean health utility decreased by 0.487 (the scale runs from 1 to - 0.594) between clinical stages 2A and 4. Emotional states, measured using the Hospital Anxiety and Depression Scale (HADS), showed worsening depression and anxiety scores as ALS progressed. Age of onset, disease onset, gender and treatment group were not predictors of EQ-5D, depression or anxiety. In conclusion, increasing severity of King's ALS Clinical Stage is associated with a progressive decrease in EQ-5D health utility. This is useful for cost-benefit analysis of new therapies and validates this ALS clinical staging system.
History
Publication status
- Published
Journal
Amyotrophic Lateral Sclerosis and Frontotemporal DegenerationISSN
2167-9223Publisher
Informa HealthcareExternal DOI
Issue
3-4Volume
15Page range
285-291Department affiliated with
- BSMS Neuroscience Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2015-11-26Usage metrics
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