Keratin dynamics: modeling the interplay between turnover and transport

Portet, Stéphanie, Madzvamuse, Anotida, Chung, Andy, Leube, Rudolf E and Windoffer, Reinhard (2015) Keratin dynamics: modeling the interplay between turnover and transport. PLoS ONE, 10 (3). e0121090. ISSN 1932-6203

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Keratin are among the most abundant proteins in epithelial cells. Functions of the keratin network in cells are shaped by their dynamical organization. Using a collection of experimentally-driven mathematical models, different hypotheses for the turnover and transport of the keratin material in epithelial cells are tested. The interplay between turnover and transport and their effects on the keratin organization in cells are hence investigated by combining mathematical modeling and experimental data. Amongst the collection of mathematical models considered, a best model strongly supported by experimental data is identified. Fundamental to this approach is the fact that optimal parameter values associated with the best fit for each model are established. The best candidate among the best fits is characterized by the disassembly of the assembled keratin material in the perinuclear region and an active transport of the assembled keratin. Our study shows that an active transport of the assembled keratin is required to explain the experimentally observed keratin organization.

Item Type: Article
Keywords: Keratin dynamics, epithelial cells, mathematical modelling, turnover and transport
Schools and Departments: School of Mathematical and Physical Sciences > Mathematics
Subjects: Q Science
Q Science > QA Mathematics
Q Science > QA Mathematics > QA0297 Numerical analysis
Q Science > QA Mathematics > QA0299 Analysis. Including analytical methods connected with physical problems
Depositing User: Anotida Madzvamuse
Date Deposited: 22 Apr 2015 09:47
Last Modified: 01 Jul 2019 18:00

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Project NameSussex Project NumberFunderFunder Ref
Mathematical Modelling and Analysis of Spatial Patterning on Evolving SurfacesG0872EPSRC-ENGINEERING & PHYSICAL SCIENCES RESEARCH COUNCILEP/J016780/1
Unravelling new mathematics for 3D cell migrationG1438LEVERHULME TRUSTRPG-2014-149
InCeM: Research Training Network on Integrated Component Cycling in Epithelial Cell MotilityG1546EU-Horizon2020 MSCA-ITANUnset