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Faust, K, Härtel, C, Preuß, M, Rabe, H, Roll, C, Emeis, M, Wieg, C, Szabo, M, Herting, E, Göpel, W, German Neonatal Network, and NeoCirculation Project, (2015) Short-term outcome of very-low-birthweight infants with arterial hypotension in the first 24 h of life. Archives of Disease in Childhood, 100 (5). F388-F392. ISSN 0003-9888
Full text not available from this repository.Abstract
Objective To evaluate lowest mean arterial blood pressure during the first 24 h of life (minMAP24) in very-low-birthweight (VLBW) infants and to identify associations between hypotension and short-term outcome.
Design Retrospective cohort analysis of the minMAP24 of 4907 VLBW infants with a gestational age <32 weeks in correlation with clinical data. Hypotension was defined as minMAP24 being lower than the median value of all patients of the same gestational age.
Results MinMAP24 values correlated with gestational age. Median minMAP24 values of VLBW infants ≤29 weeks’ gestation were 1–2 mm Hg lower than gestational age in completed weeks. Hypotensive infants had a higher rate of intraventricular haemorrhage (IVH, 20.3% vs 15.9%, p<0.001), bronchopulmonary dysplasia (BPD, 19.2% vs 15.1%, p<0.001) and death (5.2% vs 3.0%, p<0.001). Multivariate logistic regression analyses, including potential confounders, confirmed these data. MinMAP24 was an independent risk factor for IVH (OR 0.97/mm Hg, 95% CI 0.96 to 0.99, p=0.003), BPD (OR 0.96/mm Hg, 95% CI 0.94 to 0.98, p<0.001) and mortality (OR 0.94/mm Hg, 95% CI 0.90 to 0.98, p=0.003).
Conclusions Hypotension during the first 24 h of life is associated with adverse outcomes in VLBW infants. This underlines the need for randomised controlled trials on the use of vasoactive drugs in this vulnerable patient cohort.
| Item Type: | Article |
|---|---|
| Schools and Departments: | Brighton and Sussex Medical School > Clinical and Experimental Medicine |
| Subjects: | R Medicine > RJ Pediatrics > RJ0251 Newborn infants Including physiology, care, treatment, diseases |
| Depositing User: | Judy Keogh |
| Date Deposited: | 23 Mar 2015 13:25 |
| Last Modified: | 29 Jul 2019 14:24 |
| URI: | http://sro.sussex.ac.uk/id/eprint/53484 |