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For the benefit of others: reasons why women with breast cancer participate in RCTs
journal contribution
posted on 2023-06-08, 20:21 authored by Valerie JenkinsValerie Jenkins, Lesley FallowfieldLesley FallowfieldIntroduction: Appreciation of the barriers and drivers affecting enrolment in randomised clinical trials (RCTs) is important for future trial design, communication and information provision. Method: As part of an intervention to facilitate UK multidisciplinary team communication about RCTs, women with breast cancer who discussed trials with doctors and/or research nurses completed questionnaires examining: - clarity of trial information and reasons for either accepting or declining trial entry. Results: 152 women with breast cancer completed the questionnaires; 113/152 (74%) consented to RCT enrolment. Patients’ satisfaction with communication about the trial information was very good, irrespective of participation decisions. Acceptors’ and decliners’ responses to 9/16 statements concerning decisions about trial participation differed significantly. ‘Wanting to help with doctor’s research’ influenced 100% acceptors compared to 57% of decliners (p<.001). Decliners were more likely to be ‘worried about randomisation’ (20% v 39%; p<.035) and to ‘want doctor to choose treatment rather than be randomised’ (31% v 53%; p<.031). Primary reason for trial acceptance was altruism; “I feel that others with my illness will benefit from the results of the trial”, 58/108 (54%). Conclusion: A majority of women accepted RCT entry citing altruistic motivations as the primary driver for participation. Trial design and setting (metastatic or adjuvant) had little impact on participation.
Funding
Supportive interventions in cancer.; G0004; CANCER RESEARCH UK; C54/A7374
History
Publication status
- Published
File Version
- Accepted version
Journal
Breast CareISSN
1661-3805Publisher
KargerExternal DOI
Issue
2Volume
10Department affiliated with
- Sussex Health Outcomes Research & Education in Cancer (SHORE-C) Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2015-03-19First Open Access (FOA) Date
2015-03-19First Compliant Deposit (FCD) Date
2015-03-19Usage metrics
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