Feeding inhibition by glucose loads, compared between normal and diabetic rats

Doses of glucose, fructose or mannose intragastrically, or glucose intraperitoneally, inhibit feeding in intact rats, even when the solutions are not hypertonic. In hyperphagic, polydipsic and glucosuric streptozotocin-treated rats, the inhibition is attenuated beyond detection at the same doses of glucose, while fructose and mannose effects remain. The loss of postabsorptive glucose-induced satiety in chronically diabetic rats is attributed to the changed disposal of glucose after prolonged absence of insulin.