ARA290 in a rat model of inflammatory pain

Dilley, Andrew (2013) ARA290 in a rat model of inflammatory pain. In: Ghezzi, Pietro and Cerami, Anthony (eds.) Tissue protective cytokines. Methods in molecular biology, 982 (982). Humana Press, pp. 213-225.

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Chronic pain affects as many as one in five people. A proportion of patients with symptoms of neuropathic -pain do not have clinical signs of any obvious tissue or nerve injury. Such patients include those with diffuse limb pain, back pain, and complex regional pain syndrome type 1. These patients remain a clinical enigma. However, through the development of the neuritis model, it has become apparent that local nerve inflammation in the absence of gross pathology (i.e., axonal degeneration and demyelination) may underlie part of the mechanisms of pain. In this chapter, we describe a method to induce the neuritis model. We also describe in detail a reliable method to test for mechanical allodynia and heat hyperalgesia. Data that demonstrates the potential benefits of the neuroprotective agent ARA290 in reducing pain behavior in the neuritis model are presented.

Item Type: Book Section
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
Brighton and Sussex Medical School > Division of Medical Education
Subjects: R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0346 Neurology. Diseases of the nervous system Including speech disorders
Depositing User: Andrew Dilley
Date Deposited: 13 Feb 2015 09:46
Last Modified: 25 Sep 2017 09:13
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