University of Sussex
Browse

File(s) under permanent embargo

Counterphase modulation flicker photometry: phenotypic and genotypic associations.

journal contribution
posted on 2023-06-08, 19:47 authored by A J Lawrance-Owen, Jenny BostenJenny Bosten, R E Hogg, G Bargary, P T Goodbourn, J D Mollon
The OSCAR test, a clinical device that uses counterphase flicker photometry, is believed to be sensitive to the relative numbers of long-wavelength and middle-wavelength cones in the retina, as well as to individual variations in the spectral positions of the photopigments. As part of a population study of individual variations in perception, we obtained OSCAR settings from 1058 participants. We report the distribution characteristics for this cohort. A randomly selected subset of participants was tested twice at an interval of at least one week: the test-retest reliability (Spearman's rho) was 0.80. In a whole-genome association analysis we found a provisional association with a single nucleotide polymorphism (rs16844995). This marker is close to the gene RXRG, which encodes a nuclear receptor, retinoid X receptor ?. This nuclear receptor is already known to have a role in the differentiation of cones during the development of the eye, and we suggest that polymorphisms in or close to RXRG influence the relative probability with which long-wave and middle-wave opsin genes are expressed in human cones.

History

Publication status

  • Published

File Version

  • Published version

Journal

Journal of the Optical Society of America A

ISSN

1084-7529

Publisher

Optical Society of America

Issue

4

Volume

31

Article number

A226-A231

Department affiliated with

  • Psychology Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2015-01-28

First Compliant Deposit (FCD) Date

2015-01-28

Usage metrics

    University of Sussex (Publications)

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC