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Determining the functional role of TRPC channels in primary cells

journal contribution
posted on 2023-06-08, 19:47 authored by Su Li, Martin Gosling, Chris Poll
Although the TRPC members of the mammalian transient receptor potential TRP cation channel family were the first to be described in 1995, the depth of knowledge of TRPC channels has fallen behind that of their counterparts in the TRPV and TRPM subfamilies in the intervening years. The complexities and controversies of TRPC channel composition and regulation have hindered their progress as therapeutic targets in the drug discovery environment to date, however embracing these challenges as opportunities may bring TRPC channels to the forefront of the discovery of novel therapies for many diseases. These challenges and opportunities of exploring TRPC channels as therapeutic targets are highlighted and discussed in this review with respect to respiratory diseases. © Springer-Verlag 2005.

History

Publication status

  • Published

Journal

Pflugers Archiv European Journal of Physiology

ISSN

0031-6768

Publisher

Springer-Verlag

Issue

1

Volume

451

Page range

43-52

Department affiliated with

  • Chemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2015-01-26

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