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Optimizing pyramided transgenic Bt crops for sustainable pest management
journal contribution
posted on 2023-06-08, 19:37 authored by Yves Carrière, Neil CrickmoreNeil Crickmore, Bruce E TabashnikTransgenic crop pyramids producing two or more Bacillus thuringiensis (Bt) toxins that kill the same insect pest have been widely used to delay evolution of pest resistance. To assess the potential of pyramids to achieve this goal, we analyze data from 38 studies that report effects of ten Bt toxins used in transgenic crops against 15 insect pests. We find that compared with optimal low levels of insect survival, survival on currently used pyramids is often higher for both susceptible insects and insects resistant to one of the toxins in the pyramid. Furthermore, we find that cross-resistance and antagonism between toxins used in pyramids are common, and that these problems are associated with the similarity of the amino acid sequences of domains II and III of the toxins, respectively. This analysis should assist in future pyramid design and the development of sustainable resistance management strategies.
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Publication status
- Published
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- Published version
Journal
Nature BiotechnologyISSN
1087-0156Publisher
Nature Publishing GroupExternal DOI
Issue
2Volume
33Page range
161-168Department affiliated with
- Biochemistry Publications
Notes
Online first editionFull text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2015-01-19First Compliant Deposit (FCD) Date
2021-03-09Usage metrics
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