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Optimizing pyramided transgenic Bt crops for sustainable pest management

journal contribution
posted on 2023-06-08, 19:37 authored by Yves Carrière, Neil CrickmoreNeil Crickmore, Bruce E Tabashnik
Transgenic crop pyramids producing two or more Bacillus thuringiensis (Bt) toxins that kill the same insect pest have been widely used to delay evolution of pest resistance. To assess the potential of pyramids to achieve this goal, we analyze data from 38 studies that report effects of ten Bt toxins used in transgenic crops against 15 insect pests. We find that compared with optimal low levels of insect survival, survival on currently used pyramids is often higher for both susceptible insects and insects resistant to one of the toxins in the pyramid. Furthermore, we find that cross-resistance and antagonism between toxins used in pyramids are common, and that these problems are associated with the similarity of the amino acid sequences of domains II and III of the toxins, respectively. This analysis should assist in future pyramid design and the development of sustainable resistance management strategies.

History

Publication status

  • Published

File Version

  • Published version

Journal

Nature Biotechnology

ISSN

1087-0156

Publisher

Nature Publishing Group

Issue

2

Volume

33

Page range

161-168

Department affiliated with

  • Biochemistry Publications

Notes

Online first edition

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2015-01-19

First Compliant Deposit (FCD) Date

2021-03-09

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